| 货号 | 70645-50mg |
| 描述 | DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2.1 When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1.2 The IC50 values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively.3 The IC50 for the inhibition of human recombinant COX-1 after the same time intervals is 9 µM.3 DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kargman, S.,Wong, E.,Greig, G.M., et al. Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells. Biochemical Pharmacology 52, 1113-1125 (1996). 2.Seibert, K.,Masferrer, J.,Needleman, P., et al. Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney. British Journal of Pharmacology 117, 1016-1020 (1996). 3.Johnson, J.L. . (2000). 4.Rosenstock, M.,Danon, A. and Rimon, G. PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity. Biochimica et Biophysica Acta 1440, 127-137 (1999). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 411.3 |
| 分子式 | C17H12BrFO2S2 |
| CAS号 | 88149-94-4 |
| 稳定性 | ≥ 1 year |
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