| 货号 | 6043/50 |
| 别名 | N4-(1,3-Benzodioxol-5-ylmethyl)-6-( |
| 供应商 | Tocris |
| 生物活性 | Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 386.84 |
| 分子式 | C19H18N4O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Fukudaet al (2016) Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochem. 17 9. PMID: 27207629. Wanget al (2016) 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm.Res. 65 61. PMID: 26613980. Denicolet al (2013) Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci.Rep. 3 1266. PMID: 23405280. Liuet al (2005) A small-molecule agonist of the Wnt signaling pathway. Angew.Chem.Int.Ed.Engl. 44 1987. PMID: 15724259. |