| 货号 | 1821/50 |
| 别名 | 4-(3-Chlorophenyl)-1,7-diethylpyrid |
| 供应商 | Tocris |
| 生物活性 | Orally active PDE4 inhibitor (IC50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 313.79 |
| 分子式 | C17H16ClN3O |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 191219-80-4 |
| 参考文献 | Moriuchiet al (2003) Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur.J.Pharmacol. 470 57. PMID: 12787831. Aokiet al (2001) Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. J.Pharmacol.Exp.Ther. 298 1142. PMID: 11504812. Aokiet al (2000) A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. J.Pharmacol.Exp.Ther. 295 255. PMID: 10991987. |