| 货号 | 2173/50 |
| 别名 | 1,2,3,4,8,9,10,11-Octahydro[1,4]dia |
| 供应商 | Tocris |
| 生物活性 | Selective 5-HT2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Stimulates intracellular Ca2+ mobilization in CHO cells expressing human 5-HT2C receptors (EC50 = 72 nM). Reduces food intake in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 262.78 |
| 分子式 | C15H18N2.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 57756-45-3 |
| 参考文献 | Dunlopet al (2004) Identification of cycloalkyl[b][1,4]benzodiazepinoindoles as novel 5-HT2C receptor agonists. Fund.Clin.Pharmacol. 18 (Suppl.1) 145. Sabbet al (2004) Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg.Med.Chem.Lett. 14 2603. PMID: 15109661. |