| 货号 | 2494/50 |
| 别名 | 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester dihydrobromide |
| 供应商 | Tocris |
| 生物活性 | High affinity (pKi = 7.5), potent histamine H4 receptor full agonist (pEC50 = 7.3). Displays moderate affinity for H3 receptors (pKi = 6.0) and weak partial agonist activity at H2receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 323.05 |
| 分子式 | C4H11N5S.2HBr |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 98021-17-1 |
| 参考文献 | Limet al (2008) Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors. J.Pharmacol.Exp.Ther. 327 88. PMID: 18635748. Limet al (2006) Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J.Med.Chem. 49 6650. PMID: 17154494. Sterket al (1986) The influence of guanidio and isothiourea groups in histaminergic compounds on H2-activity. Agents Actions 18 137. PMID: 2942013. |