| 货号 | 1686/25 |
| 别名 | (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-meth |
| 供应商 | Tocris |
| 生物活性 | A potent and selective inhibitor of the anandamide membrane transporter (AMT), in water-soluble emulsion (for details see TocrisoveTM 100, Cat. No. 1684). IC50 values for inhibition of AMT are 4 - 11 mM. Displays negligible agonist activity at the hVR1 receptor and very weak action at CB1 and CB2 receptors. Ki values are > 5 - 10 mM at CB1 and CB2. Active in vivo. VDM 11 also available (pure oil dissolved in ethanol, Cat. No. 1392). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 409.61 |
| 分子式 | C27H39NO2 |
| CAS号 | 313998-81-1 |
| 参考文献 | Gubelliniet al (2002) Experimental Parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. J.Neurosci. 22 6900. PMID: 12177188. Bisognoet al (2001) The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. Eur.J.Biochem. 268 1982. PMID: 11277920. De Petrocelliset al (2001) The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J.Biol.Chem. 276 12856. PMID: 11278420. De Petrocelliset al (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett. 483 52. PMID: 11033355. |