| 货号 | 4612/50 |
| 别名 | Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 338.4 |
| 分子式 | C20H22N2O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Jayamanneet al (2006) Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br.J.Pharmacol. 147 281. PMID: 16331291. Piomelliet al (2006) Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 12 21. PMID: 16834756. Hohmannet al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435 1108. PMID: 15973410. |