| 货号 | 2661/50 |
| 别名 | N-Trityl-3-pyridinemethanamine |
| 供应商 | Tocris |
| 生物活性 | Slow afterhyperpolarization (sAHP) channel blocker; reduces sAHP in hippocampal slice preparations. Displays no effect on Ca2+ currents or the time course of sAHP/sIAHP. Exhibits potent inhibition of KCNQ1 and KCNQ2, but differential effects at other KCNQs. Rescues memory retrieval in dopamine β-hydroxylase knockout mice. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 350.46 |
| 分子式 | C25H22N2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Zhanget al (2013) The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval. J.Neurosci. 33 5006. PMID: 23486971. Soh and Tzingounis (2010) The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol.Pharmacol. 78 1088. PMID: 20843955. Shahet al (2006) Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol.Pharmacol. 70 1494. PMID: 16877678. |