| 货号 | 2580/50 |
| 别名 | (Z)-5-Chloro-2,3-dihydro-3-(hydroxy |
| 供应商 | Tocris |
| 生物活性 | NSAID that preferentially inhibits COX-1 (IC50 values are < 0.03, 1.2 and > 30 μM for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hKir2.3 channel (EC50 = 402 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 320.75 |
| 分子式 | C14H9N2O3SCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 120210-48-2 |
| 参考文献 | Liuet al (2002) Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3. Eur.J.Pharmacol. 435 153. PMID: 11821021. Kirchneret al (1997) Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J.Pharmacol.Exp.Ther. 282 1094. PMID: 9262379. Moilanenet al (1988) CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro. Eicosanoids 1 35. PMID: 2856170. |