| 货号 | 2854/50 |
| 别名 | (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4- |
| 供应商 | Tocris |
| 生物活性 | 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C,α1,α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT1B,β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 419.95 |
| 分子式 | C21H29N5O2.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in water |
| CAS号 | 87760-53-0 |
| 参考文献 | Matsubaraet al (2006) Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions. Brain Res. 1112 126. PMID: 16884702. Pollardet al (1992) Effects of tandospirone in three behavioral tests for anxiolytics. Eur.J.Pharmacol. 221 297. PMID: 1358655. Hamiket al (1990) Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol.Psychiatry 28 99. PMID: 1974152. |