T2AA (50 MG)
货号：
4723/50 基本售价：
8704.9 元 规格：
50 mg
产品信息
概述| 货号 | 4723/50 |
| 别名 | (βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol |
性能| 供应商 | Tocris |
| 生物活性 | Proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50~1μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 511.09 |
| 分子式 | C15H15I2NO3< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Punchihewaet al (2012) Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J.Biol.Chem. 287 14289. PMID: 22383522. |
