| 货号 | 3037/50 |
| 别名 | 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)met |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Displays no activity against EGFR, HER2, IGF1R and PDGFR. Inhibits tumor vascularization and growth of multiple tumor types. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 238.28 |
| 分子式 | C15H14N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 204005-46-9 |
| 参考文献 | Mologniet al (2006) Inhibition of RET tyrosine kinase by SU5416. J.Mol.Endocrinol. 37 199. PMID: 17032739. Smolichet al (2001) The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-Kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood 97 1413. PMID: 11222388. Fonget al (1999) SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularisation, and growth of multiple tumor types. Cancer Res. 59 99. PMID: 9892193. |