| 货号 | 5432/50 |
| 别名 | 8-Chloro-4-(phenylthio)-1-(trifluor |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 380.77 |
| 分子式 | C16H8ClF3N4< |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Kinget al (2013) TNF-α receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice. Neurosci.Lett. 542 92. PMID: 23499961. Gururajaet al (2007) A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chem.Biol. 14 1105. PMID: 17961823. |