| 货号 | 2194/50 |
| 别名 | 6-[2-[4-[(4-Fluorophenyl)phenylmeth |
| 供应商 | Tocris |
| 生物活性 | Diacylglycerol (DAG) kinase inhibitor (IC50 = 2.8 μM); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 459.58 |
| 分子式 | C27H26FN3OS |
| 可溶性/溶解性 | Soluble to 20 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 93076-89-2 |
| 参考文献 | Nobeet al (2004) Novel diacylglycerol kinase inhibitor selectively suppressed an U46619-induced enhancement of mouse portal vein contraction under high glucose conditions. Br.J.Pharmacol. 143 166. PMID: 15289283. Boonenet al (1993) Neutrophil chemotaxis induced by the diacylglycerol kinase inhibitor R59022. Biochim.Biophys.Acta 1178 97. PMID: 8392381. Nunn and Watson (1987) A diacylglyerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets. Biochem.J. 243 809. PMID: 2821994. de Chaffoy de Courcelleset al (1985) R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet. J.Biol.Chem. 260 15762. PMID: 2999135. |