| 货号 | 2477/50 |
| 别名 | 4-[3-(Phenylmethoxy)propyl]-1H-imid |
| 供应商 | Tocris |
| 生物活性 | High affinity histamine H3 receptor ligand (pKi = 8.62) that acts as a protean agonist at recombinant and native receptors. In functional studies, activity ranges from full agonist to inverse agonist depending on system used. Displays partial agonist effects on cAMP inhibition and MAPK activity, neutral antagonist activity on histamine release and partial inverse agonism of [3H]-arachidonic acid release. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 306.32 |
| 分子式 | C13H16N2O.C2H2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in water |
| CAS号 | 177708-09-7 |
| 参考文献 | Baldiet al (2005) The H3 receptor protean agonist proxyfan enhances the expression of fear memory in the rat. Neuropharmacology 48 246. PMID: 15695163. Kruegeret al (2005) G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations. J.Pharmacol.Exp.Ther 314 271. PMID: 15821027. Gbahouet al (2003) Protean agonism at histamine H3receptorsin vitroandin vivo. Proc.Natl.Acad.Sci.USA 10011086. |