| 货号 | 0589/50 |
| 别名 | 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride |
| 供应商 | Tocris |
| 生物活性 | High affinity, selective σ1 agonist (Ki values are 2.2 and 13091 nM for σ1andσ2 receptors respectively). Selective over PCP receptors (IC50 > 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effects in vivo. Also exhibits protective effects in PC6.3 cells expressing mutant huntingtin by activating NF-κB signaling. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 353.89 |
| 分子式 | C19H27NO3.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 75 mM in DMSO |
| CAS号 | 138847-85-5 |
| 参考文献 | Hyrskyluotoet al (2013) Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway. Cell Death Dis. 4 e646. PMID: 23703391. Brownet al (2004) Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Br.J.Pharmacol. 141 233. PMID: 14691051. Mauriceet al (1999) The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (σ) receptor ligands involves both σ1 and σ2 sites. Br.J.Pharmacol. 127 335. PMID: 10385231. Suet al (1991) Sigma compounds derived from phencyclidine. Identification of PRE-084, a new selective sigma ligand. J.Pharmacol.Exp.Ther. 259 543. PMID: 1658302. |