| 货号 | 2562/50 |
| 别名 | 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahyd |
| 供应商 | Tocris |
| 生物活性 | High affinity σ2 receptor agonist (Ki values are 0.8 and 15.2 nM for σ2andσ1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 443.5 |
| 分子式 | C24H38N2O.2HCl |
| 可溶性/溶解性 | Soluble to 20 mM in water with gentle warming |
| CAS号 | 172906-90-0 |
| 参考文献 | Colabufoet al (2004) Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines. Naunyn-Schmied.Arch.Pharmacol. 370106. Colabufoet al (2003) A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder. Naunyn-Schmied.Arch.Pharmacol. 368106. Berardiet al (1996) New σ and 5-HT1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives. J.Med.Chem. 39 176. PMID: 8568804. |