| 货号 | 4566/50 |
| 别名 | 3,5-Bis[(4-nitrophenyl)methylene]-1 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of 19S regulatory particle associated deubiquitinating enzymes (DUBs), UCHL5 and USP14. Shows minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP, BAP1 and proteasome activity. Induces apoptosis by cathepsin D-dependent caspase-cleavage (IC50 = 0.5 μM). Displays antitumor activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 419.39 |
| 分子式 | C22H17N3O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | D'Arcyet al (2011) Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat.Med. 17 1636. PMID: 22057347. Berndtssonet al (2009) Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system. Int.J.Cancer 124 1463. PMID: 19089926. |