| 货号 | 2185/50 |
| 别名 | (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 316.85 |
| 分子式 | C17H16N2S.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 59474-01-0 |
| 参考文献 | Berksonet al (2005) Pilot screening programme for small molecule activators of p53. Int.J.Cancer 115 701. PMID: 15729694. Dolmaet al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285. PMID: 12676586. |