| 货号 | 0431/50 |
| 别名 | 1-(5-Chloronaphthalenesulfonyl)homo |
| 供应商 | Tocris |
| 生物活性 | Selective MLCK inhibitor (Ki values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca2+ entry (SOCE). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 361.29 |
| 分子式 | C15H17ClN2O2S.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| CAS号 | 105637-50-1 |
| 参考文献 | Varnaiet al (2009) STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 30 118. PMID: 19187978. Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377. PMID: 1605572. Setoet al (1991) Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. Eur.J.Pharmacol. 195 267. PMID: 1874276. Hidaka and Hagiwara (1987) Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci. 8162. |