| 货号 | 4732/50 |
| 别名 | 4-Methyl-2-(1-piperidinyl)quinoline |
| 供应商 | Tocris |
| 生物活性 | Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 226.32 |
| 分子式 | C15H18N2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in 1eq. HCl with gentle warming |
| 参考文献 | Milleret al (2011) Novel chemical inhibitor of TRPC4 channels. Probe Reports from the Molecular Libraries Program. PMID: 22049577. Milleret al (2011) Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels. J.Biol.Chem. 286 33436. PMID: 21795696. |