| 货号 | 1858/50 |
| 别名 | 4-(5-Aminopentyl)imidazole dihydrobromide; VUF 4702 |
| 供应商 | Tocris |
| 生物活性 | Potent and highly selective histamine H3 receptor antagonist (pA2 = 8.4); displays > 30000-fold selectivity over H1 and H2 receptors. Can act as a partial agonist in SK-N-MC cells expressing human H3 receptors. Produces antinociception, possibly via a non-H1, -H2 or -H3 receptor-mediated mechanism, following central administration in vivo. |
| 运输条件 | Ambient |
| 存放说明 | Ambient |
| 计算分子量 | 315.05 |
| 分子式 | C8H15N3.2HBr |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 34973-91-6 |
| 参考文献 | Wielandet al (2001) Constitutive activity of histamine H3 receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H3 antagonists. J.Pharmacol.Exp.Ther. 299 908. PMID: 11714875. Houghet al (1999) Antinociceptive activity of impentamine, a histamine congener, after CNS administration. Life Sci. 64 PL79. PMID: 10072195. Vollingaet al (1995) Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole. J.Med.Chem. 38 266. PMID: 7830269. |