| 货号 | 5364/50 |
| 别名 | 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methyle |
| 供应商 | Tocris |
| 生物活性 | Dynamin inhibitor (IC50 values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis in vitro. Prevents botulinum A internalization in hippocampal neurons. Also protects against botulinum A-induced muscle paralysis in rats. Analog of Dynasore (Cat. No. 2897). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 338.31 |
| 分子式 | C18H14N2O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | McCluskeyet al (2013) Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic 14 1272. PMID: 24025110. Harperet al (2011) Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism. J.Biol.Chem. 286 35966. PMID: 21832053. |