| 货号 | 2896/50 |
| 别名 | 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-t |
| 供应商 | Tocris |
| 生物活性 | Selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC50 values are 6.2 and 5.3 μM respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or NaV1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 355.39 |
| 分子式 | C18H21N5O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 349085-38-7 |
| 参考文献 | Taylor-Clarket al (2008) Prostaglandin-induced activation of nociceptive neurons via direct interactions with TRPA1. Mol.Pharmacol. 73 274. PMID: 18000030. McNamaraet al (2007) TRPA1 mediates formalin-induced pain. Proc.Natl.Acad.Sci.USA 10413525. |