| 货号 | 2531/50 |
| 别名 | (3α,5α)-3-Hydroxy-3-methyl-pregnan-20 |
| 供应商 | Tocris |
| 生物活性 | Potent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L,α3β1γ2Landα1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 332.53 |
| 分子式 | C22H36O2 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming and to 20 mM in ethanol |
| CAS号 | 38398-32-2 |
| 参考文献 | Lydenet al (2000) Effect of ganaxolone in a rodent model of cerebral hematoma. Stroke 31 169. PMID: 10625734. Ungardet al (2000) Modification of behavioral effects of drugs in mice by neuroactive steroids. Psychopharmacology 148 336. PMID: 10928304. Carteret al (1997) Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high affinity, steroid modulator of the γ-aminobutyric acidA receptor. J.Pharmacol.Exp.Ther. 280 1284. PMID: 9067315. |