| 货号 | 0541/50 |
| 别名 | HA 1077 |
| 供应商 | Tocris |
| 生物活性 | Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Suppress MMP-2 expression and induce apoptosis in glioblastoma cells in vivo. Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 327.83 |
| 分子式 | C14H17N3O2S.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 75 mM in DMSO |
| CAS号 | 103745-39-7 |
| 参考文献 | Denget al (2010) Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitroand in vivo. Cancer Biol Ther. 875 875. PMID: 20364104. Swardet al (2000) Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum. J.Physiol. 522 33. PMID: 10618150. Satohet al (1996) Neuroprotective properties of a protein kinase inhibitor against ischaemia-induced neuronal damage in rats and gerbils. Br.J.Pharmacol. 118 1592. PMID: 8842419. Araiet al (1993) Inhibition by the protein kinase inhibitor HA-1077 of the activation of NADPH oxidase in human neutrophils. Biochem.Pharmacol. 46 1487. PMID: 8240400. Shirotaniet al (1991) A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits proliferation of bovine vascular smooth muscle cells in culture. J.Pharmacol.Exp.Ther. 259 738. PMID: 1941621. |