| 货号 | 0884/25 |
| 别名 | (±)-trans-10,11-Dihydroxy-5,6,6a,7,8 |
| 供应商 | Tocris |
| 生物活性 | A potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 303.79 |
| 分子式 | C17H17NO2.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 50 mM in DMSO |
| CAS号 | 123039-93-0 |
| 参考文献 | Kholiet al (1993) Dihydrexidine: a new potent peripheral dopamine D1 receptor agonist. Eur.J.Pharmacol. 235 31. PMID: 8100195. Tayloret al (1991) Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in monkeys. Eur.J.Pharmacol. 199 389. PMID: 1680717. Brewsteret al(1990)Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. J.Med.Chem. 33 1756. PMID: 1971308. Lovenberget al (1989) Dihydrexidine, a novel selective high potency, full dopamine D-1 receptor agonist. Eur.J.Pharmacol. 166 111. PMID: 2572425. |