| 货号 | 0668/50 |
| 别名 | 2-Amino-5-(2-aminoethyl)-4-methylth |
| 供应商 | Tocris |
| 生物活性 | Highly selective H2 agonist, slightly more potent than histamine itself. Only a weak antagonist at H3 and has no activity at H1 receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 319.06 |
| 分子式 | C6H11N3S.2HBr |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 142437-67-0 |
| 参考文献 | Jarajapuet al (2006) Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP. Eur.J.Pharmacol. 547 116. PMID: 16920098. Coruzziet al (1993) The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion. Naunyn Schmiedebergs Arch.Pharmacol. 348 77. PMID: 8377843. Poliet al(1993)In vitro cardiac pharmacology of the new histamine H2 receptor agonist amthamine; comparisons with histamine and dimaprit. Agents Actions 40 44. PMID: 8147269. Erikset al (1992) Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole. J.Med.Chem. 35 3239. PMID: 1507209. |