| 货号 | 2564/50 |
| 别名 | 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 377.01 |
| 分子式 | C20H21B2NO5 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Achantaet al (2006) A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome. Mol.Pharmacol. 70 426. PMID: 16636137. Achantaet al (2005) Preferential killing of cancer cells with wild-type p53 by boronic chalcones. Proc.Am.Assoc.Cancer Res.Abstr. 466162. |