| 货号 | 4754/50 |
| 别名 | N-(3-Bromophenyl)-3-[(hexahydro-1H- |
| 供应商 | Tocris |
| 生物活性 | Selective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 437.35 |
| 分子式 | C19H21BrN2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Chopraet al (2012) The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2 1492. PMID: 23200855. Tayloret al (2011) A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem.Biol. 6 540. PMID: 21370928. |