CGI1746
货号：
18414-25mg 基本售价：
8666.0 元 规格：
25 mg
产品信息
概述| 货号 | 18414-25mg |
| 描述 | CGI1746 is a potent, selective inhibitor of Bruton’s tyrosine kinase (BTK; IC50 = 1.9 nM), a non-receptor tyrosine kinase that is important in B lymphocyte development.1,2 It blocks both auto-and trans-phosphorylation of BTK by occupying an SH3 binding pocket in the un-phosphorylated enzyme. CGI1746 prevents B-cell antigen receptor-mediated B lymphocyte proliferation and suppresses FCγRIII-induced TNFα, IL-1β, and IL-6 production in macrophages.1 It reduces cytokine levels within joints and ameliorates symptoms in a mouse model of autoantibody-induced arthritis.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.di Paolo, J.A.,Huang, T.,Balazs, M., et al. Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nat.Chem.Biol. 7(1), 41-50 (2011).
2.Akinleye, A.,Chen, Y.,Mukhi, N., et al. Ibrutinib and novel BTK inhibitors in clinical development. J. Hematol. Oncol. 6(59), (2013).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 579.7 |
| 分子式 | C34H37N5O4 |
| CAS号 | 910232-84-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
