β-Muricholic Acid
货号：
20287-10mg 基本售价：
8652.0 元 规格：
10 mg
产品信息
概述| 货号 | 20287-10mg |
| 描述 | β-Muricholic acid (β-MCA) is a natural murine-specific bile acid.1 In mice, a cholesterol and β-MCA diet (1% β-MCA, 1% cholesterol, 0.5% cholic acid, plus an additional 1% β-MCA) reduced liver HMG-CoA reductase levels and enzymatic activity levels to near zero compared to control mice fed a diet lacking the additional 1% β-MCA.2 In a lithogenic mouse model, β-MCA administration (2% cholesterol and 0.5% cholic acid plus 0.5% β-MCA) for eight weeks dissolved 100% of pre-existing gallstones.3 |
| 别名 | 5β-Cholanic Acid-3α,6β,7β-triol;β-MCA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Eyssen, H.J.,Parmentier, G.G. and Mertens, J.A. Sulfate bile acids in germ-free and conventional mice. European Journal of Biochemistry 66(3), 507-514 (1976).
2.Fujino, Y.,Nakayama, K.,Yoshimura, K., et al. Suppression of hepatic HMG-CoA reductase activity by β-muricholic acid in mice fed a diet containing cholesterol and cholic acid. Jpn. J. Pharmacol. 46(4), 421-423 (1988).
3.Wang, D.Q.-H. and Tazuma, S. Effect of β-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice. J. Lipid. Res. 43(11), 1960-1968 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 408.6 |
| 分子式 | C24H40O5 |
| CAS号 | 2393-59-1 |
| 稳定性 | ≥ 2 years |
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