TC-E 5001 (50 MG)
货号：
5049/50 基本售价：
8615.7 元 规格：
50 mg
产品信息
概述| 货号 | 5049/50 |
| 别名 | 3-(4-Methoxyphenyl)-5-[[[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole |
性能| 供应商 | Tocris |
| 生物活性 | Dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50>19μM). Inhibits Wnt signaling and stabilizes Axin2 levels. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 409.46 |
| 分子式 | C20H19N5O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Shultzet al (2012) [1,2,4]Triazole-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J.Med.Chem. 55 1127. PMID: 22260203. |
