| 货号 | 2089/50 |
| 别名 | 1'-[2-[4-(Trifluoromethyl)phenyl]eth |
| 供应商 | Tocris |
| 生物活性 | CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. Also inhibits α1A,α1D and 5-HT1Areceptors. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 426.86 |
| 分子式 | C21H21F3N2O2.HCl |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO |
| CAS号 | 300815-41-2 |
| 参考文献 | Mirzadeganet al (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 275 25562. PMID: 10770925. Clarket al (1983) Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'piperidin]-2(1H)-ones. J.Med.Chem. 26 657. PMID: 6842505. |