| 货号 | 2581/50 |
| 别名 | 4-(Phenylmethyl)-1-piperazineacetic |
| 供应商 | Tocris |
| 生物活性 | Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 μM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 392.5 |
| 分子式 | C23H28N4O2 |
| 可溶性/溶解性 | Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO |
| CAS号 | 315183-21-2 |
| 参考文献 | Petersonet al (2009) Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3. J.Med.Chem. 52 5721. PMID: 19708658. Puttet al (2006) Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat.Chem.Biol. 2 543. PMID: 16936720. |