| 货号 | 1002/50 |
| 别名 | 3-(4-[4-Chlorophenyl]piperazin-1-yl |
| 供应商 | Tocris |
| 生物活性 | A highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and > 1000-fold selectivity over 5-HT2, D1 and D5receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 436.21 |
| 分子式 | C18H19N4Cl.3HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 158985-00-3 |
| 参考文献 | Pillaiet al (1998) Human D2 and D4 dopamine receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respectively. Neuropharmacology 37 983. PMID: 9833627. Bristowet al (1997) Schizophrenia and L-745, 870 a novel dopamine D4 receptor antagonist. TiPS 18 186. PMID: 9226994. Patelet al (1997) Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. J.Pharmacol.Exp.Ther. 283 636. PMID: 9353380. Kulagowskiet al (1996) 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human D4 receptor. J.Med.Chem. 39 1941. PMID: 8642550. |