| 货号 | 3597/50 |
| 别名 | N-Methyl-N-[3-[3-[2-thienylcarbonyl |
| 供应商 | Tocris |
| 生物活性 | Potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site (Ki values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively). Displays ~ 10-fold selectivity for α1 subunit-containing receptors (EC50 values are 2.6, 24, 60 and 77 nM for α1β2γ2,α2β2γ2,α3β3γ2 and α5β2γ2 receptors respectively). Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity in vivo and is orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 376.43 |
| 分子式 | C20H16N4O2S |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 325715-02-4 |
| 参考文献 | Petroskiet al (2006) Indiplon is a high-affinity positive allosteric modulator with selectivity for α1 subunit-containing GABAA receptors. J.Pharmacol.Exp.Ther. 317 369. PMID: 16399882. Fosteret al (2004) In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine sedative-hypnotic. J.Pharmacol.Exp.Ther. 311 547. PMID: 15256538. Sullivanet al (2004) Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor. J.Pharmacol.Exp.Ther. 311 537. PMID: 15256540. |