| 货号 | 1816/50 |
| 别名 | 2-Amino-6-methyl-4-propyl-[1,2,4]tr |
| 供应商 | Tocris |
| 生物活性 | Potent phosphodiesterase (PDE) 4 inhibitor (IC50 = 35 nM for inhibition of [3H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 207.23 |
| 分子式 | C9H13N5O |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 27277-00-5 |
| 参考文献 | Zhaoet al (2003) Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram J.Pharmacol.Exp.Ther. 305 565. PMID: 12704225. Kaulenet al (1989) Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram. Brain Res. 503 229. PMID: 2557965. Wachtel (1983) Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology 22 267. PMID: 6302550. |