| 货号 | 3532/50 |
| 别名 | [(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-H |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of Wnt signaling. Induces an increase in Axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Negative control exo-IWR (Cat. No. 3947) available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 409.44 |
| 分子式 | C25H19N3O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 1127442-82-3 |
| 参考文献 | Luet al (2009) Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg.Med.Chem.Lett. 19 3825. PMID: 19410457. Chenet al (2008) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chem.Biol. 5100. |