| 货号 | 4936/50 |
| 别名 | 8-Chloro-11-(4-methyl-4-oxido-1-pip |
| 供应商 | Tocris |
| 生物活性 | Metabolite of clozapine (Cat. No. 0444). Activates human muscarinic designer receptors (DREADDs). Silences hippocampal neurons expressing hM4DREADDsin vitro. Suppresses food intake in hyperphagic mice with hM3Dq-expressing, LMO4-deficient, paraventricular hypothalamic neurons. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 342.82 |
| 分子式 | C18H19ClN4O |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 20 mM in water |
| 参考文献 | Zamanet al (2014) LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia. J.Neurosci. 34 140. PMID: 24381275. Armbrusteret al (2007) Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc.Natl.Acad.Sci.U.S.A. 104 5163. PMID: 17360345. Eiermannet al (1997) The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. Br.J.Clin.Pharmacol. 44 439. PMID: 9384460. |