| 货号 | 5301/50 |
| 别名 | N,N'-[Thiobis(2,1-ethanediyl-1,3,4-t |
| 供应商 | Tocris |
| 生物活性 | Allosteric glutaminase (GLS1) inhibitor (IC50 = 3.3 μM). Selective for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 524.68 |
| 分子式 | C24H24N6O2 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Leet al (2012) Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell.Metab. 15 110. PMID: 22225880. Shuklaet al (2012) Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J.Med.Chem. 55 10551. PMID: 23151085. DeLaBarreet al (2011) Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 50 10764. PMID: 22049910. |