A 971432 ( )
货号：
5766/50 基本售价：
8615.7 元 规格：
50 mg
产品信息
概述| 货号 | 5766/50 |
| 别名 | 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective S1P5 agonist (EC50 values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 366.24 |
| 分子式 | C18H17Cl2NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH and to 100 mM in 1eq. HCl |
| 参考文献 | Hobsonet al (2015) Discovery of A-971432, an orally bioavailable selective sphingosine-1-phosphate receptor 5 (S1P5) agonist for the potential treatment of neurodegenerative disorders. J.Med.Chem. 58 9154. PMID: 26509640. |
