FRAX1036
货号：
20711-25mg 基本售价：
8582.0 元 规格：
25 mg
产品信息
概述| 货号 | 20711-25mg |
| 描述 | FRAX1036 is a selective inhibitor of p21-activated kinase 1 (PAK1), a serine/threonine kinase downstream of Rac1 and Cdc42 that is involved in tumorigenesis. It can induce apoptosis in breast cancer cells and has been shown to potentiate the activity of the microtubule stabilizing agent, docetaxel (Item No. 11637).1 Disruption of PAK1 via FRAX1036 has been used to inhibit oncogenic KRAS signaling in non-small cell lung cancer cells.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ong, C.C.,Gierke, S.,Pitt, C., et al. Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents. Breast Cancer Res. 17:59, (2015).
2.Mortazavi, F.,Lu, J.,Phan, R., et al. Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. BMC Cancer 15(381), (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 518.1 |
| 分子式 | C28H32ClN7O |
| CAS号 | 1432908-05-8 |
| 稳定性 | ≥ 2 years |
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