GSK583
货号：
19739-250mg 基本售价：
8582.0 元 规格：
250 mg
产品信息
概述| 货号 | 19739-250mg |
| 描述 | GSK583 is a selective inhibitor of RIP-like interacting CLARP kinase (RICK also known as RIP2 kinase; IC50 = 5 nM).1 RIP2 Kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines. In an ex vivo human translational model using intestinal mucosal tissue from inflammatory bowel disease patients, GSK583 inhibited both TNF-α and IL-6 production with an IC50 value of 200 nM.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Haile, P.A.,Votta, B.J.,Marquis, R.W., et al. The identification and pharmacological characterization of 6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a highly potent and selective inhibitor of RIP2 kinase. Journal of Medicinal Chemistry 59(10), 4867-4880 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 398.5 |
| 分子式 | C20H19FN4O2S |
| CAS号 | 1346547-00-9 |
| 稳定性 | ≥ 2 years |
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