| 货号 | 18509-250mg |
| 描述 | The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species.1,2 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM).3 It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation.4 4-ANI is used to study the role of PARP activity in various cell systems.5,6,7 |
| 别名 | 4-Aminonaphthalimide;4-ANI; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Davar, D.,Beumer, J.H.,Hamieh, L., et al. Role of PARP inhibitors in cancer biology and therapy. Current Medicinal Chemistry 19(23), 3907-3921 (2012). 2.Mathews, M.T. and Berk, B.C. PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2. Arteriosclerosis, Thrombosis, and Vascular Biology 28, 711-717 (2008). 3.Banasik, M.,Komura, H.,Shimoyama, M., et al. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. The Journal of Biological Chemisty 267(3), 1569-1575 (1992). 4.Schlicker, A.,Peschke, P.,Burkle, A., et al. 4-Amino-1,8-naphthalimide: A novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int.J.Radiat.Biol. 75(1), 91-100 (1999). 5.Issaeva, N.,Thomas, H.D.,Djureinovic, T., et al. 6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Research 70(15), 6268-6276 (2010). 6.Horton, J.K.,Stefanick, D.F.,Gassman, N.R., et al. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA Repair (Amst) 12(9), 774-785 (2013). 7.Luo, Q.,Li, Y.,Lai, Y., et al. The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells. Journal of Toxicological Sciences 40(3), 349-363 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 212.2 |
| 分子式 | C12H8N2O2 |
| CAS号 | 1742-95-6 |
| 稳定性 | ≥ 2 years |
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