(±)17(18)-EpETE
货号：
50861-500ug 基本售价：
8512.0 元 规格：
500 ug
产品信息
概述| 货号 | 50861-500ug |
| 描述 | The epoxygenase pathway is one of the three major branches of eicosanoid biosynthesis.1,2 However, the cytochrome P450 metabolites of eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310) have been little studied relative to arachidonate epoxygenase metabolites. (±)17(18)-EpETE is biosynthesized by the stereospecific epoxidation of the ω-3 bond of EPA. (±)17(18)-EpETE at 100 nM was found to be a potent and selective activator of BK-type calcium activated potassium ion channels in vascular smooth muscle cells.3 It is possible that some of the physiologic effects of fish oil-enhanced diets could be due to this epoxygenase metabolite. |
| 别名 | (±)17,18-EEQ;(±)17,18-epoxy Eicosatetraenoic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fitzpatrick, F.A. and Murphy, R.C. Cytochrome P-450 metabolism of arachidonic acid: Formation and biological actions of “epoxygenase”-derived eicosanoids. Pharmacological Reviews 40, 229-241 (1989).
2.Oliw, E.H.,Bylund, J. and Herman, C. Bisallylic hydroxylation and epoxidation of polyunsaturated fatty acids by cytochrome P450. Lipids 31, 1003-1996 (1996).
3.Lauterbach, B.,Barbosa-Sicard, E.,Wang, M.H., et al. Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activators. Hypertension 39, 609-613 (2002).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 318.5 |
| 分子式 | C20H30O3 |
| 稳定性 | ≥ 1 year |
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