Pristimerin
货号：
13621-50mg 基本售价：
8512.0 元 规格：
50 mg
产品信息
概述| 货号 | 13621-50mg |
| 描述 | Monoacylglycerol lipase (MAGL) hydrolyzes the endogenous cannabinoid 2-arachidonoyl glycerol (2-AG), terminating its capacity to activate cannabinoid receptors. Pristimerin is a naturally occurring terpenoid that potently inhibits MAGL (IC50 = 93 nM).1 Its actions are rapid, reversible, and noncompetitive.1 Pristimerin (1 µM) significantly increases 2-AG levels in isolated rat neurons,1 indicating that it inhibits endogenous MAGL in cultured cells. Moreover, it does not increase levels of palmitoyl ethanolamide, suggesting that pristimerin does not affect the activity of fatty acid amide hydrolase (FAAH). |
| 别名 | Celastrol methyl ester;NSC 99281; |
性能| 供应商 | Cayman |
| 应用文献 |
1.King, A.R.,Dotsey, E.Y.,Lodola, A., et al. Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chemistry & Biology 16, 1045-1052 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 464.6 |
| 分子式 | C30H40O4 |
| CAS号 | 1258-84-0 |
| 稳定性 | ≥ 2 years |
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