CAY10662
货号：
11042-500ug 基本售价：
8512.0 元 规格：
500 ug
产品信息
概述| 货号 | 11042-500ug |
| 描述 | 17(R),18(S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EpETE), a natural cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid, is known to reduce the contraction rate of spontaneously beating heart cells and to protect neonatal rat cardiomyocytes against arrhythmias induced by β-adrenergic agonists (EC50 = ~ 1-2 nM).1 CAY10662 is a 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50< 1 nM) over its parent compound.1 At concentrations 1,000-fold higher than required for the effect on cardiomyocytes, 1-5 μM CAY10662 exerts weak dose-dependent soluble epoxide hydrolase inhibition.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Falck, J.R.,Wallukat, G.,Puli, N., et al. 17(R), 18(S)-epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: Structure-activity relationships and stable analogues. Journal of Medicinal Chemistry 54(12), 4109-4118 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 340.5 |
| 分子式 | C19H36N2O3 |
| CAS号 | 1184844-74-3 |
| 稳定性 | ≥ 2 years |
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