(±)14(15)-EpETE
货号：
10173-500ug 基本售价：
8512.0 元 规格：
500 ug
产品信息
概述| 货号 | 10173-500ug |
| 描述 | EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.1,2 Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE (Item No. 50651) which are prime candidates for the actual active mediator.3 However, the CYP450 metabolites of eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310) have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined. |
| 别名 | (±)14,15 EEQ;(±)14,15-epoxy Eicosatetraenoic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chataigneau, T.,Félétou, M.,Duhault, J., et al. Epoxyeicosatrienoic acids, potassium channel blockers, and endothelium-dependent hyperpolarization in the guinea-pig carotid artery. British Journal of Pharmacology 123, 574-580 (1998).
2.Fisslthaler, B.,Popp, R.,Kiss, L., et al. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature 401, 493-497 (1999).
3.Baron, A.,Frieden, M., and Bény, J.L. Epoxyeicosatrienoic acids activate a high-conductance, Ca2+-dependent K+ channel on pig coronary artery endothelial cells. Journal of Physiology 504, 537-543 (1997).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 318.5 |
| 分子式 | C20H30O3 |
| CAS号 | 131339-24-7 |
| 稳定性 | ≥ 1 year |
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