| 货号 | 10172-500mg |
| 描述 | Lyso-PC is the ubiquitous lipid species generated following phospholipase A2(PLA2) hydrolysis of phosphatidylcholine. The hydrolysis of phospholipids by arachidonoyl-selective PLA2s is the initiating event in many eicosanoid-based signal transduction pathways.1 Many other reactions also generate phosphatidylcholine species with a free hydroxyl group in the sn-2 position. Lyso-PC augments inflammation through effects on adhesion molecules and growth factors, monocytes, and macrophages.1,2,3 The lymphocyte G protein-coupled receptor G2A binds lyso-PC as a specific ligand with a Kd of 65 nM; this receptor also binds the related phospholipid sphingosyl phosphorylcholine.4 |
| 别名 | LPC;1-Palmitoyl-sn-glycero-3-Phosphocholine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Balsinde, J.,Winstead, M.V., and Dennis, E. Phospholipase A2 regulation of arachidonic acid mobilization. FEBS Letters 531, 2-6 (2002). 2.Kume, N., and Gimbrone, M.A., Jr. Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells. Journal of Clinical Investigation 93, 907-911 (1994). 3.Yan, J.J.,Jung, J.S.,Lee, J.Y., et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Nature Medicine 10(2), 161-167 (2004). 4.Kabarowski, J.H.S.,Zhu, K.,Le, L.Q., et al. Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A. Science 293, 702-705 (2001). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 495.6 |
| 分子式 | C24H50NO7P |
| CAS号 | 17364-16-8 |
| 稳定性 | ≥ 1 year |
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